TECH OFFERS

Melatonin is an antioxidant with numerous medical and nutraceutical applications. It plays an important role in the body and assists in synchronising circadian rhythms and sleep. Melatonin is most commonly administered orally at a dosage of 2 mg for treating primary insomnia. Beside melatonin tablets, consumption of tropical fruits such as pineapples, oranges and bananas was also found to result in elevated melatonin concentration in the human body. However, the effective absorption of melatonin through oral administration varies from individuals, and diabetics or the elderly would not able to consume enough of such fruits to achieve the required melatonin concentration for treating insomnia. Melatonin is also suitable for transdermal delivery due to its low required dose, short biological half-life, low molecular weight. This technology, in the form of a sleeping mask, is enriched with tropical fruit extracts such as pineapples, oranges, and bananas, combined with melatonin encapsulated in nanovesicles. Beyond its revitalising impact on facial skin, this dual-purpose mask also promotes tranquil sleep, offering an appealing solution for individuals seeking respite from sleep troubles without resorting to conventional melatonin tablets.  The technology is particularly advantageous for those navigating health restrictions, such as prolonged use of melatonin tablets or managing high blood sugar, and for those who prefer to regulate sugary fruit intake.  This technology comprises of a proprietary blend encompassing specific constituents and a composition that has been substantiated through clinical investigation. Rigorous safety assessments on the mask's formulation, involving 60 healthy volunteers, confirmed a non-irritating score of 0.00.  The fruit extracts used in this blend are gathered using environmentally friendly "green solvents" through the utilisation of a cold extraction method. The melatonin used is also originating from the fruit extract and is encapsulated within nanovesicles. This encapsulation technology enhances melatonin release, skin permeation, and formulation stability. In vitro studies indicate a melatonin release rate of 50% after 15 minutes and 100% after 30 minutes, and a cumulative skin permeation of >200 ng/ml in 8 hours.  Skincare products, e.g. sleeping mask, serum Cosmeceutical, e.g. rejuvenating serum Health care products, e.g. alternative sleep aid The global sleep aids market size was valued at US$59.8 billion in 2020, and is projected to reach $111.9 billion by 2030, registering a CAGR of 6.9% from 2021 to 2030 (Allied Market Research, 2023).  The global beauty facial mask (BFM) market is estimated at US$6.8 billion in 2022 and is expected to expand at an impressive CAGR of 5.1% during the forecast years of 2022-2032 (Fact.MR, 2023). The global melatonin market is expected to experience significant growth, exceeding US$217.9 million by 2033, with demand driven by growing awareness among consumers about benefits of melatonin supplements. It is likely to expand at 8.2% CAGR during 2023 to 2033 (Future Market Insights, 2023).  This technology provides an innovative alternative to conventional sleeping aids through the utilisation of extracts from tropical fruits such as pineapples, oranges, and bananas, combined with plant-based melatonin encapsulated in nanovesicles for enhanced delivery into the skin.  melatonin, insomnia, sleeping mask, tropical fruits, nanovesicle Personal Care, Cosmetics & Hair, Wellness & Spa

This technology offer features a natural remedy for scar reduction. The formulation integrates 15% shallot (Allium ascalonicum) extract and 0.01% quercetin, both well-known for their antioxidant potency and anti-wrinkle effects. These active ingredients are also known for their scar treatment properties. This formulation is positioned as an innovative alternative for individuals afflicted with elevated scars arising from surgical interventions, acne, or various traumatic injuries.  The shallot extract is obtained by employing environmentally conscious solvents alongside an ultrasonic extraction technique that is simpler and more efficient than conventional processes. Further elevating its efficacy, the encapsulation of pivotal quercetin within nanotechnology constructs facilitates heightened skin absorption.  The technology comprises a proprietary blend encompassing specific constituents and know-how, featuring: Shallot extracts that are gathered using environmentally friendly “green solvents” through the utilisation of a cold extraction method. The methodology yields amplified quantities of active constituents when juxtaposed with conventional water or alcohol-based methodologies, at an increase of 300% and 30% respectively. High concentration of quercetin originating from the shallot extract and pure quercetin are encapsulated within nanovesicles.   Encapsulation technology which enhances quercetin release, skin permeation, and formulation stability. The composition has been substantiated through clinical investigation over 14-28 days to yield non-irritating outcomes. A methodical safety appraisal involving a cohort of 22 healthy volunteers distinctly underscores the formulation's non-irritating attributes, substantiated by an appreciable score of 0.15. The shallot extract obtained through this extraction technology has a wide range of potential applications. This technology can be deployed to the cosmetic, cosmeceutical, and pharmaceutical industries, particularly: Skincare products e.g., anti-scar products  Cosmeceuticals e.g., scar treatment products Herbal skincare / cosmeceutical products The global scar treatment market was valued at USD 23.5 billion in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 9.9% from 2023 to 2030. (Grand View Research, 2023)  The unique value proposition of this scar treatment lies in the combination of extraction, formulation and encapsulation know-how, creating a versatile formulation that incorporates 15% shallot (Allium ascalonicum) extract and 0.01% quercetin encapsulated in nanovesicles for improved skin permeation and product stability. Moreover, comprehensive clinical trials have been undertaken to ascertain the product's safety.  The technology owner also possesses the capabilities to substantiate the efficiency of the solution across an extensive spectrum of scar types through empirical validation, offering partners seeking to embrace efficacious and dependable remedies a compelling advantage to address the burgeoning scar treatment domain. quercetin, scar, scar treatment, thai onion, thai shallot, nanovesicle Personal Care, Cosmetics & Hair, Wellness & Spa

Eggs are a widely popular protein source, however, egg production requires a significant amount of natural resources. Hence, this technology aims to substitute chicken eggs with plant-based alternatives, which would lead to a reduced environmental impact. Rice bran is the hard outer layer of rice, a byproduct of the rice milling process which is pressed for oil and then discarded. Using rice bran as a source of protein reduces waste and increases resource efficiency, making it a strong potential candidate as an alternative protein source to be produced in Thailand, which is the 6th largest rice producer according to the FAO. This product is high in protein (comparable to chicken eggs), which is hydrolyzed to increase bioavailability, and does not contain cholesterol and saturated fat. It is fit for health and fitness enthusiasts, vegetarians, flexitarians and people with an egg allergy. Proprietary precision hydrolysis and subcritical water technology is used to extract the protein. The carbohydrates are hydrolysed, and separated from the proteins under specific pressure and temperature Proteins are then hydrolysed and spray dried into final product, which is a powder that requires reconstitution This process has already been scaled up to commercial scale for B2B customization   - Culinary applications e.g. omelette, tamago - Egg replacer e.g. in waffles, certain bakery products - High protein supplementation in food MarketsandMarkets shows that the total global plant-based egg replacer market is valued at $831M USD, with the APAC market consuming around 20% of that market share. A large majority of these products are made using mung bean or other legumes, which can confer a beany taste or contain allergens. Rice-based products are very familiar to the Asian market, and hence are more likely to be adopted. Hydrolyzing proteins produces smaller chains of amino acids or peptides which increases absorption by the body and improves muscle recovery. This rice bran protein has a lighter color, no bitterness, and salty taste as compared to other rice bran proteins. Clinical studies have been conducted on this rice bran protein to show that the peptides are nutraceuticals with antihypertensive and antioxidants properties Alternative Protein, Rice Bran Protein, Plant Protein, Protein Extraction, By-product, Biorefinery Foods, Ingredients, Sustainability, Food Security

Anti-corrosion is important for piping systems because corrosion can lead to several problems including reduced flow capacity, leaks and ruptures, contamination, increased maintenance costs and reduced lifespan. While there are several approaches to mitigate these problems, a possible approach is to utilise thermoplastic materials which are lightweight, durable, and resistant to corrosion. This technology is a thermoplastic piping system lined with HDPE/LDPE linings that is corrosion-resistant, do not generate any waste (waste material can be recycled) and has a reduced carbon footprint. The piping system is easy to assemble and install, providing long service lives due to the high-quality thermoplastic materials being deployed in the system. By laying these thermoplastic pipes underground using native soil without sand-bedding, a reduction in CO2 is achieved and offers users a sustainable piping solution against conventional piping materials. In combination with proprietary welding technologies, the technology has the lowest rate of leakages with high guarantee of preservation of drinking water quality when used in water piping systems. The technology owner is seeking for co-development and test-bedding opportunities with asset owners to integrate the technology into their infrastructure, particularly with hydrogen producing and transporting companies. The technology is a thermoplastic piping system that exhibits the following features: Efficient corrosion protection against aggressive media Excellent product properties (static puncture resistance) Long service life (minimum service life is 50 years, up to 100 years) Maintenance free – pipework is homogenous, longitudinally force-locked and leak-tight Reduced carbon footprint compared to conventional piping materials Easy to install using permanently leak-tight welding technologies Suitable for clean and efficient trenchless installation Black piping and fitting are resistant to UV and corrosion free against chemicals The technology is a thermoplastic piping system that has been successfully deployed in several industries. Possible applications include (but are not limited to): Hydrogen Plant Hydrogen transport (or transportation of natural gas) Semiconductor Photovoltaic Life Science Water and Wastewater Chemical Processing Oil & Gas Mining Power Plant Municipal Shipbuilding Environmental Engineering Irrigation Long life expectancy (up to 100 years) Maintenance free Simple and economical installation Toxic free and recyclable hdpe, high density polyethylene, thermoplastic, piping systems, anti-corrosion, corrosion resistance, low leakage, polymers, hydrogen gas pipe Materials, Plastics & Elastomers, Chemicals, Polymers, Environment, Clean Air & Water, Mechanical Systems, Sustainability, Circular Economy

Manual built environment inspection suffers from multiple issues such as shortage of manpower, human error and miscommunication. To overcome these issues, there is a need for an automated and centralized inspection system capable of detecting multiple defects of interest and presenting the inspection results in an easy to access format. The technology presented uses data acquired from LiDAR and Cameras mounted on an autonomous robot to inspect building interiors and external facades. The system utilizes an AI engine and can accurately detect defects such as cracks, holes, and other built imperfections stated in building quality guidelines such as CONQUAS. Defect reports can be autonomously generated after the acquired image and LiDAR data has been processed by the AI analytics engine.  The system is composed of an autonomous robot with a mounted camera and LiDAR and has the following features - Support for multiple hardware platforms such as wheeled robots and drones to allow the use of most suitable means of inspection. AI based defect detection for cracks, holes, stains, cornerness, and other structural and visual defects at >3mm unevenness. Capability to inspect for air quality, hazard detection and safety monitoring (PPE Detection). Simple and intuitive user interface with customizable repots minimizing possibility of miscommunication. Generation of defect reports compliant to Singapore Building and Construction Authority recommendations for Built Environment - CONQUAS. Defect and user management system. Capability to integrate with external Building Information Management (BIM) systems and third party apps. The system can be used for digitalization and autonomous inspection of built environments. It covers both the indoor and outdoor inspection by allowing use of multiple robot platforms. With the removal of manual inspection requirements, the system helps improve the consistency and objectiveness of inspections and helps in increasing productivity. The technology is applicaple for tasks related to management of a building from construction to maintenance. By automating and centralizing the built environment inspection, the system improves productivity, significantly reduces the time required by the inspection process, and improves the safetly of the personnel involved. The solution is useful during the entire lifecycle from construction to maintainence and provides automated reports compliant to recommendations of the Singapore Building and Construction Authority. The solution can potentially cut down the time required for inspection by several hours per residential or commercial unit. Building Indoor and Facade Inspection, Built Environment Inspection, CONQUAS, CIS-7, Quality Assessment Electronics, Sensors & Instrumentation, Infocomm, Video/Image Analysis & Computer Vision, Artificial Intelligence

Skin rejuvenating products that contain proteins, growth factors, and amino acids are commonly known for its potent anti-aging and skin condition-improving effects. Many exogenous protein and growth factors from placenta extracts have been reported as a potential regenerative medicine to replace or repair damaged cells, tissues, and organs, in which the stimulation of dermal fibroblasts and collagen production have also been found. However, the rejuvenating effects of natural proteins and growth factors on the skin are normally applied either via mesotherapy by using transdermal hypodermic injection or topically along with cosmeceutical aesthetic procedure, resulting in a common cause of pain and the requirement of health professionals for injection.  This solution proposes the incorporation of microspicules, which take the form of micron-sized needles, into skin care product formulations that contain high concentration of natural proteins and growth factors. This can overcome the limitations of conventional approaches and more effectively deliver hydrophilic macromolecular proteins and growth factors, bypassing the layer of stratum corneum, entering into the skin, and leading to skin regeneration. Such self-administered transdermal systems can also improve patient compliance and are generally inexpensive. The technology owner is seeking collaboration opportunities with industry players to increase product innovations in market niches within the cosmeceutical product sphere. The technology comprises the use of natural proteins and growth factors extracted from goat placenta as active ingredients for skin rejuvenating products. In addition, micron-sized needle, known as microspicule, is used as a skin penetration enhancer to improve the skin permeability of hydrophilic macromolecular proteins and growth factors.    The green extraction method uses an aqueous solution and without organic solvents to produce high yield of active compounds such as total protein and growth factors from goat placenta, at a lower cost. The skin ampoule formulation contains high concentration of natural proteins and growth factors (e.g. EGF, FGF, IGF-1 and TGF-β1, etc.) in a hydrating serum base with microspicules (needle-like structure with the tip growing out from two opposite sites at 11.89 µm wide and 176.77 µm long). This safe, pain-free, and self-care application can be used as topical and localised treatment on the skin. After applying this formulation onto the skin, natural proteins and growth factors can penetrate into and through the skin. The technology has been dermatologically- and irritation-tested by evaluating the acute cutaneous tolerance of a cosmetic product on adult subjects by single patch test on 21 subjects with every skin type (19 female and 2 males) aged 30 to 59 years old and is considered safe and non-irritating.  This technology can be deployed in the cosmetic industry, especially in the development of hydrating and anti-aging products. The product formulation contains: Natural proteins and growth factors from goat placenta extract as active ingredients with potent skin rejuvenating and anti-aging properties. Hydrating serum base containing microspicules which can be used as the skin delivery system, as well as an anti-aging and moisture control product. This technology is also applicable for skin care products in the anti-ageing therapeutic market. Green and low-cost extraction technology to produce natural proteins and growth factors from goat placenta at high yield Proprietary formulation achieving high concentration of natural proteins and growth factors Formulated with microspicules for more effective, passive delivery of macromolecular and hydrophilic active ingredients for natural and potent skin rejuvenating properties placenta extract, natural protein, growth factors, anti-aging, skin care, skin rejuvenating Personal Care, Cosmetics & Hair, Wellness & Spa, Healthcare, Pharmaceuticals & Therapeutics

Root rot diseases in food crops are devastating diseases currently without solution. Examples of such diseases are the Basal Stem Rot in oil palms, Fusarium Wilt in bananas, and Phytophthora Root Rot in citrus.  While fungicides have in vitro efficacy, most do not possess phloem mobility and therefore cannot reach the roots to effect treatment. Thus, despite widespread usage of fungicides, root rot diseases are still inadequately treated or are not treated at all. This Nano Delivery Technology imparts phloem mobility to fungicides, allowing them to reach the roots from the application site to treat and protect the crops. The technology is designed as a ready-to-use adjuvant that works with commercialised fungicides. Growers can independently and safely nano encapsulate the fungicides with basic mixing equipment and a simple, one-step mixing process. This technology is patent-pending and ready to market. Imparts phloem mobility to fungicides  Enables fungicides to effectively reach roots from the application site Sustains a residual effect for up to 12 months per treatment Encapsulation material is naturally derived and biodegradable Works with commercialised fungicides such as Hexaconazole 75% WG, Dimethomorph 80% WG and Tricyclazole 75% WDG Simple, one-step mixing process can be handled independently by growers Proven effective in treating root rot disease in oil palms  Helps growers cut losses by 75% The technology can be easily scaled to treat other phloem restricted diseases such as Citrus Greening and address problem statements such as weeds and nutrient deficiencies in food crops. Climate change that results in extreme weather conditions such as heat waves and floods exacerbates the spread and intensity of root rot diseases in food crops. At this time, there is also no known or effective treatment for such devastating diseases. The combined global economic losses from root rot diseases in oil palms, bananas, and citrus alone are more than US$ 5 billion per year. Treats root rot diseases that are currently without solution Works with commercialised fungicides Reduces reapplication frequencies hence labour requirements Accelerates ESG compliance through reduced usage of fungicides Increases growers' climate change resilience Patent pending Ready to market agriculture, agritech, agrifood tech, agrifoodtech, food security, nanotechnology, nano, nano materials, nano encapsulation, agrochemical, crop care, crop protection, herbicide, fertiliser, fertilizer, pesticide, fungicide, root rot, phytophthora, basal stem rot, fusarium wilt, panama, huanglongbing, hlb, citrus greening, delivery technology, precision delivery, delivery, encapsulation, oil palm, HLB, nano delivery, ganoderma, adjuvant, nano particles Materials, Nano Materials, Chemicals, Agrochemicals, Life Sciences, Agriculture & Aquaculture, Additives, Sustainability, Food Security

Probiotic bacteria play a pivotal role in stimulating T cell-dependent immune responses, offering protection against bacterial infections, and addressing various gut-related conditions resulting in the healthy gut health. This technology features specially designed formulations using meticulously selected microbial probiotic strains with exceptional attributes and natural bioactive compounds with prebiotic and functional properties to enhance gut health and bolster immune support. In particular, the formulations feature a functional, prebiotic ingredient that promotes beneficial gut bacteria and prepared from mulberry through a patent-pending process.  With a team of specialists capable of customising probiotic functions to specific needs, they are able to select, isolate and culture advanced probiotic strains, as well as conduct pharmacological activities for functional claims. Depending on customers’ needs, e.g. facilitating growth of gut beneficial microorganisms, prevent infections, or reduce inflammation in the digestive system, the team can customise the blend of ingredients.  Synbiotic formulations by blending carefully selected probiotic strains with in-house mulberry extract or other prebiotics Selected probiotic strains exhibit, through in vitro and in vivo studies, ability to withstand the digestive system and no red blood cell hemolysis, adhere effectively to intestinal mucosa, inhibit gastrointestinal pathogens, reduce inflammation, and promote microbial balance in the gut Metagenomic analysis was also conducted, revealing an increase in the diversity of beneficial bacteria population residing in the gut   Supplements: Customisable into various forms, including capsules, tablets, and powders, making them a convenient option for individuals seeking targeted gut health support Functional Beverages: Probiotics can be added to various beverages like kombucha, smoothies, and fruit juices to provide a convenient way for consumers to incorporate them into their diet Yogurt and Fermented Dairy Products Pet Food: Probiotics are also used in pet food products to support the digestive health and overall well-being of animals   In 2022, the global prebiotics and probiotics market was estimated to be worth approximately US$6 billion and US$58 billion respectively (Research and Markets, 2022). In Thailand, it currently stands at around US$250 million with potential growth. The advent of the COVID-19 pandemic has heightened global health awareness, prompting people worldwide to seek ways to strengthen their immune systems. The company possesses the capability to produce the selected probiotic strains and mulberry-based prebiotic, as well as provides the expertise in probiotics and prebiotics product development aimed at enhancing gut health and bolstering immune support. Their core know-how is built on three key pillars: Extensive research to continually advance products in metagenomic study Selected probiotic strains for effectively improving gut health and immune support Functional properties of product such as anti-inflammatory and antioxidant to enhance overall well-being probiotic, prebiotic, functional ingredient, gut health, immunity Personal Care, Nutrition & Health Supplements, Foods, Ingredients, Sustainability, Sustainable Living

High blood sugar in diabetes can gradually block blood vessels, reducing blood flow to the feet and leading to foot ulcers caused by pressure, nerve issues, and poor circulation. Traditionally, these problems are detected with the monofilament test, but it is not preventive and can miss early signs of ulceration. We offer two innovative technologies for real-time diabetic foot monitoring: 1. A high-resolution sensor pad has 2,500 pressure sensors to monitor underfoot pressure accurately in a static position. 2. A smart insole, designed for real-time monitoring, alerts users to potential ulcer risks by detecting high- pressure areas. It not only provides alerts but also offers guidance on reducing pressure.  Both these technologies can be an affordable alternative and incredibly user-friendly. By taking a proactive approach to diabetic foot care, the technology providers hope to prevent the development of foot ulcers and related complications, positively impacting the lives of millions worldwide. This cutting-edge technology, features a smart insole with eight pressure sensors, enabling real-time pressure monitoring in the foot. This data is seamlessly transmitted via Bluetooth to a smartphone app and then to the cloud for comprehensive analysis. The smart insole alerts users to high-pressure areas and recommends actions to prevent ulceration. We collaborate with different hospitals, rehabilitation clinics, and specialized shoe stores, using our smart insole to collect valuable data from actual patients. By harnessing the power of machine learning and consulting with expert medical professionals, we proactively detect issues early and provide customized solutions to enhance diabetic foot care. The primary application for this technology is for Diabetic Foot Ulcer Prevention where the smart insole proactively prevents diabetic foot ulcers by monitoring and alerting to high-pressure areas. Nevertheless there are other potential technology application areas as listed below:  Fall Risk Prediction for Older adults: Predicts and prevents falls in older adults through real-time monitoring. Injury Risk Analysis: Assesses and mitigates injury risks for various activities, providing injury prevention insights. Rehabilitation Support: Aids in rehabilitation by tracking progress and offering data-driven training insights. Sports Performance Monitoring: Enhances sports performance by monitoring activity and offering tailored recommendations (like Golf, Running). Custom Shoe Recommendations: Recommends ideal footwear by analyzing foot pressure data for perfect fit and comfort. Diabetes is one of the major causes of amputation, blindness, stroke, end-stage renal failure, kidney failure, and heart attacks in this region. According to the International Diabetes Federation, ~66 million people were suffering from diabetes in Europe in 2017. The number is expected to increase to ~81 million by 2045.  The global foot ulcer sensors markets size is valued at 159.52 million in 2022 and is predicted to reach 211.86 million by the year 2031 at a 3.3% CAGR during the forecast persion for 2023-2031. Foot ulcers are a common complication of diabetes and peripheral artery disease that, if neglected can result in catastrophic illness like amputations. Diabetes causes nerve damage over time and due to the lack of sensitivity patients cannot feel bruising or cuts on their feet. The mortality rate associated with Diabetic Foot Ulcers is ~5% in the first 12 months and increases up to 42% by the end of 5 years.  This smart insole technology monitors underfoot pressure in real-time and alerts users to prevent ulcers in diabetic foot. It also works for fall and injury risk analysis for elderly people.It can be combined with a high-resolution sensor pad technology that monitors underfoot pressure in a static position The key differentiators are the affordability, easy of use, and the effectiveness in preventing a serious health problem which affects millions of diabetic patients worldwide.  Diabetes, Diabetic Foot, Diabetic Ulcers, Foot Ulcer Management, smart insole, insole, foot pressure measurement, sensor, sensor pad, foot pad Electronics, Sensors & Instrumentation, Healthcare, Diagnostics, Medical Devices, Telehealth, Medical Software & Imaging