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Rising global temperatures have increased energy demands for cooling, driving up greenhouse gas emissions and worsening climate change. To address these issues, radiative cooling offers a passive, energy-efficient solution by emitting heat through infrared radiation in the 8–13 µm range, where minimal atmospheric absorption occurs, allowing heat to escape into space. This can significantly reduce energy consumption while providing a sustainable cooling. The technology owner has developed an innovative droplet-shaped coating specifically designed for building roofs and construction materials. This cutting-edge coating efficiently dissipates heat through radiation, lowering surface temperatures by 1-3°C and reducing electricity consumption by 5-15%. Crafted from a clear polymer and applied through a cost-effective spraying process, this cooling coating preserves the original colour of the substrate. It offers a powerful solution to combat rising temperatures and reduce the carbon footprint, making it ideal for homeowners, construction material manufacturers, and businesses seeking to lower energy consumption and operating costs without compromising the visual appeal of their properties. The technology owner is interested in R&D collaboration and test-bedding with building materials manufacturers, property developers, and construction companies. The technology is also available for out-licensing to paint developers and manufactures. Droplet-like Structures: Induce Mie scattering, enhancing emissivity in the 8-13 µm range, allowing efficient heat dissipation through the atmosphere into outer space Non-toxic Formulation: Made from a clear, silicone-based elastomer that is safe for environments Radiative Cooling: Achieve temperature reduction of up to 3.94°C, particularly effective in tropical climates Transparency: Maintains the original colour and aesthetic appeal of the substrate Versatile Application: Can be applied on various surfaces, including glass, wood, metal sheets, and roof tiles Low-Cost and Scalable: Offers an affordable, scalable solution with easy spray-coating application using a commercial spray gun Potential applications of this cooling technology include, but are not limited to: Building Applications: Ideal for rooftops, exterior walls, and façades to improve cooling efficiency Automotive: Can be applied to car exteriors to reduce heat buildup Facilities in Hot Climates: Suitable for transportation, storage systems, and other outdoor infrastructures Droplet-like infrared hot spots induce Mie scattering, enhancing emissivity Cost-effective solution through scalable spray-coating method Suitable for a wide range of materials and surfaces Effective in tropical climates with high solar irradiance and humidity Radiative cooling film, spray coating, building materials, green buildings Materials, Composites, Chemicals, Coatings & Paints, Green Building, Heating, Ventilation & Air-conditioning

Stomata, tiny pores on the surface of leaves, are opened or closed under the control of a pair of guard cells for gas exchange with the atmosphere. Through these pores, plants uptake the carbon dioxide necessary for photosynthesis and release water by transpiration, which enhances the uptake of nutrients from the roots. Therefore, regulation of stomatal openings is essential for plant growth and survival in response to various environmental conditions.  Improper regulation or dysfunction of stomata can lead to drying out and wilting of vegetables and flowers, resulting in loss of freshness during transportation and hence, wastages. Following a study to improve plants’ drying tolerance and productivity by controlling the opening and closing of plant pores, the research team has identified natural compounds that have the effect of closing the stomata to preserve freshness and successfully developed more potent analogs.  The research team is looking for companies to partner in joint development of applications such as sprays and volatile sheets as freshness retention agents for vegetables and flowers. Freshness preservatives based on analogs of a natural compound found in plants of the order Brassicales Up to 66 times more potent than the natural compound, offering drought resistance to plants Maintains freshness of leafy vegetables and flowers by preventing drying and wilting through the closing the stomata  Application timing is flexible, can be applied whenever drought resistance is needed Suitable for water-based formulations These compounds can be used for the vegetable and flower distribution industry. They could be formulated into various formats to be delivered via direct application, spraying, and volatilisation through packaging materials. By delivering the naturally occurring components of this technology to the leaves and flowers of vegetables and flowering plants, the pores can be closed for an extended period, preventing drying and fading. Unlike existing solutions like abscisic acid derivatives, this compound does not have side effects such as growth inhibition and seed germination suppression. stomata, freshness preservation, drying preservation Chemicals, Agrochemicals, Life Sciences, Agriculture & Aquaculture, Organic, Sustainability, Food Security

Singapore is ranked second highest among developed countries for incidence of diabetes. Previously, glucose monitoring is performed through a needle prick test or capillary blood glucose test. Compared with blood testing, sweat testing offers the advantages of non-invasiveness, portability, and persistence. Analysis and detection of biomarkers in sweat can assist in the prevention, diagnosis, and especially monitoring of chronic diseases.  Wearable devices have been extensively explored in the last decade owing to their lightweight, bendability, stretchability, and ease of integration with human interfaces. Optical wearables are also known for their potential capability to perform remote sensing and detection of multi-parameters at the same time. Despite the rapid advancement in wearable optical sensors, one of the greatest challenges is the capability of multiplexed detection or multifunctionality on a single device. To overcome this limitation, micro-lasers offer unique advantages in terms of signal amplification and narrow linewidth. Strong light interactions between optical microcavities and biomolecules would therefore lead to distinctive lasing signals for sensing. However, there are no laser emitting based device which have been invented for physiological and clinical sensing applications on human before. This technology has developed the first laser emitting bandage for multiplexed detection through a non-invasive wearable laser device. The smart bandage can quickly detect metabolites in 2 minutes through sweat secreted on human skin. The technology owner is seeking collaborations with medical institutions to extend this technology to patients health monitoring or daily monitoring. This new technology is formed by embedding tiny laser sensors in a hydrogel patch. The bandage uses laser light emitted from the bandage to identify tiny fluctuations of glucose level in sweat and can offer a record low Limit of Detection (LOD). In addition, the device can detect multiple metabolites at the same time to help monitor health conditions more precisely. To obtain an active microlaser with biochemical sensing functions, a wearable thin film laser is developed by encapsulating cholesteric liquid crystal (CLC) droplets in a flexible hydrogel thin film. Each single CLC microdroplet serves as a WGM microresonator. The three-dimensional cross-linked hydrophilic polymer serves as the adhesive layer to allow small molecules to penetrate from human tissue to the surface of droplet laser resonators. Due to the high-quality factor of the whispering gallery mode (WGM) resonator, subtle changes in the liquid crystal droplets will be amplified, resulting in a wavelength shift in the laser emission spectra, which can then be applied for sensing and monitoring metabolite. Using a laser emitting technology, the flexible bandage is able to perform multianalyte sensing and detection of metabolites.  The market potential is substantial, with hundreds of millions of patients requiring daily glucose monitoring. Additionally, the device can be adapted to track multiple metabolites, further broadening its market scope. There are two primary factors that contribute to the appeal of this device. Firstly, it enables monitoring through sweat, eliminating the need for blood samples. Secondly, the technology is both cost-effective and affordable. Previous studies have investigated the possibility of using surface-enhanced Raman scattering, photonic crystals-based structural color, and polarized microscope for sweat sensing. This technology offers several advantages:  1. This device fulfils the required dynamic range, envisioned to be applied to daily health monitoring for low-cost and disposable usage. 2. This device is able to detect any desired target metabolites by simply modifying the CLC microdroplets. By embedding modified CLC microdroplets within a PAAm hydrogel film, both flexibility and physiological sensing capabilities on human skin was achieved, including lactate, glucose, and urea. The testing results has successfully attained remarkable levels of sensitivity and minimal limits of lactate, glucose, and urea detection. 3. This platform is very versatile. By altering the components of the droplets or the hydrogel substrate itself, the structure of microdroplets in the hydrogel film can be adjusted to any lasing wavelengths. Glucose Sensor, Micro Laser, Liquid Crystal, Hydrogel Materials, Nano Materials, Electronics, Lasers, Optics & Photonics, Healthcare, Diagnostics, Medical Devices

Controlling air pollution, particularly from PM 2.5 particulate matter, is crucial for protecting human health and the environment. These microscopic particles can penetrate deep into the respiratory system, causing serious health issues such as respiratory illnesses, cardiovascular problems, and even premature death. PM 2.5 is a leading cause of poor air quality, especially in densely populated regions of Asia, where industrial emissions, vehicle exhaust, and biomass burning are prevalent. Reducing this pollution is vital to minimizing its harmful health effects and improving air quality.  To address this pressing issue, this technology has been developed that focuses on air purification through an automatic hybrid air purification tower based on a wet scrubber system. This system can capture particles as small as 0.3 microns, significantly reducing PM2.5 levels in the air. The hybrid power system ensures that it operates with lower electricity consumption compared to traditional scrubbers, making it both energy-efficient and effective. Additionally, this technology uses water instead of packing materials reducing waste generation. By leveraging this technology, urban environments can see a marked improvement in air quality, leading to better health outcomes and a cleaner atmosphere for all.  The technology owner seeks collaborations in environmental sustainability, urban development, and public health to support scaling, co-development, R&D collaboration and licensing.   The system draws in polluted air via an exhaust fan, passing it through two layers of high-speed spray nozzles that enhance water surface tension to capture particles as small as 0.3 microns. The purified air is then disinfected using ultraviolet germicidal irradiation (UVGI) technology and released at breathing level, supported by a propeller for airflow control. A hybrid power system reduces electricity usage during daylight, and water is recycled and sterilized through ozone technology and a filtration system, ensuring efficient, sustainable operation.  Air Capacity: 60,000 m3/h. Dust Trap Efficiency: Dual cyclonic nozzle spray and a redesigned PM trap plate to enhance surface tension, improving particle capture efficiency. Particle Trap: >2.5 micron. Mode of disinfection: Mechanical filtration and ozone.   Disinfection rate: Targeted to be above 99% (bacteria, virus and fungi). Water usage: 50L/day. Urban Areas and Public Spaces: Cities with high pollution levels are primary markets for outdoor air purifier towers. Governments are focusing on air quality improvement initiatives in public spaces, parks, and along highways.  Private Sector: Commercial real estate developers, especially in projects targeting high-end residential or mixed-use developments, can utilize air purifier towers as part of their environmental and wellness-focused features, such as in luxury estates, hospitals, or educational campuses.  Hospitality and Tourism: Hotels and resorts in polluted regions may also adopt outdoor air purifiers to improve their guests' well-being, offering cleaner outdoor spaces. The global air purifier market was valued at USD 15.94 billion in 2023 and is projected to grow at a CAGR of 7.1%, reaching over USD 25.5 billion by 2030. The Asia-Pacific region, accounting for 45% of global revenue, is expected to grow at 7.8%, driven by urbanization and increased awareness of pollution's health risks. Key sectors include residential, commercial, and industrial applications, with growing demand in public spaces, real estate, and hospitality for air quality improvement. Advanced Air Purification Technology: Cutting-edge filtration systems remove particulate matter (PM2.5, PM10).   Environmental Sustainability: Utilizes water in a Venturi scrubber effectively minimizes waste.  Energy-Efficient and Smart Design: Integrates an air quality sensor to monitor PM2.5 levels in real-time and automatically adjusts operational speed on air quality data for optimal efficiency.  Aesthetic Integration: Aesthetically designed to blend into modern architectural spaces, enhancing both air quality and the visual environment.  Electronics, Sensors & Instrumentation, Green Building, Heating, Ventilation & Air-conditioning, Sustainability, Sustainable Living

Water plays a vital role in various biological and industrial processes, but its effectiveness can be enhanced by modifying its molecular structure. This Ultra-Low Frequency (ULF) platform technology leverages ULF electromagnetic waves to alter the properties of water, aiming to improve its performance in specific applications. By applying low-frequency electromagnetic fields, this technology has been observed to affect water's oxidation-reduction potential (ORP), potentially increasing its antioxidative properties. Empirical data suggests that ULF-treated water may enhance cellular hydration and support metabolic functions in biological system. The technology’s ability to alter water at the molecular level offers potential benefits for agriculture, health and wellness, and food and beverage (F&B) processing. The technology owner is seeking potential collaborators: Companies or individuals, interested in integrating this breakthrough technology into their products or exploring new applications across industries such as agriculture, health and wellness, and the F&B sector. Companies or individuals who are looking to acquire the intellectual property (IP). The IP can be specifically carved out for various applications, allowing flexibility and tailored use across different sectors. ULF Electromagnetic Wave Application: The technology uses ULF electromagnetic waves to alter the properties of water by using time varying frequencies and a combination of pulsating AC wave currents along with a DC component of the generated field. Antioxidant Enhancement: By reducing the ORP of water, the technology boosts its antioxidative properties without the need for additional chemicals or additives. Importantly, this process does not make the water more alkaline. No Consumables Required: The device operates without the need for filters, chemicals, or other consumables, allowing for continuous, long-term use with minimal maintenance. The ULF electromagnetic wave technology demonstrates versatile potential across various sectors, with empirical evidence suggesting its applicability in areas such as health and wellness, agriculture, F&B, and industrial water treatment. It has the potential to  Health and Wellness: Antioxidative Benefits: The reduced ORP may enhance water's ability to neutralize free radicals, supporting general health in consumers. Metablic Support: The technology has the potential to enhance molecular energy dynamics to promote improved cellular health and overall metabolic function in the body.  Agriculture: Improved Plant Hydration and Growth: The enhanced capillary action of ULF-treated water allows for more efficient absorption and nutrient delivery in plants. This can optimize crop yield, making it useful for irrigation in agriculture. The improved water absorption can result in healthier plants, faster growth, and better nutrient uptake. Food and Beverage Industry: Extended Shelf Life: The technology can be applied to extend the shelf life of beverages, such as juices, by maintaining their freshness and reducing the need for preservatives. This reduces waste and ensures better product quality over time. Improved Taste and Texture: ULF treatment can reduce bitterness, astringency, and harsh flavors in beverages like coffee, tea, juices, and spirits, enhancing the overall taste profile and consumer experience. It also accelerates the aging process in wines and liquors, producing smoother and more palatable beverages in less time. Cosmetics and Skincare: Antioxidant-Rich Water: The water’s enhanced antioxidative properties could be integrated into cosmetic products and skincare formulations, potentially improving the effectiveness of hydration-based products and promoting healthier skin by neutralizing oxidative stress. Chemical-Free Enhancement: This technology utilizes a pure physical treatment to boost the water’s properties. Additionally, it enhances the taste and extends the shelf life of beverages without any added chemicals. Sustainable and Long-Term Use: No filters or consumables are required for the long-term application of the technology, ensuring a sustainable and hassle-free solution. Electronics, Health and Wellness, Food and beverages, Water, Personal Care, Agriculture, Antioxidant Personal Care, Wellness & Spa, Nutrition & Health Supplements, Manufacturing, Chemical Processes, Foods, Processes

Harmful algal bloom (HAB) releases toxins that can contaminate drinking water, causing illness for animals and humans. The National Centers for Coastal Ocean Science (NCCOS) estimated that the annual economic impact of HABs in the US is $10-100 million. Physical and chemical methods can be employed to deal with these, but they have several limitations. This technology is a 3D structure environmental friendly silica-based hydrogel, which has long-term effect on algal bloom control as well as pathogen control. It is capable of long-acting sustained release and precision dosing. This allows it to effectively replace the existing heavy metal algaecides on the market and solve the problem of indiscriminate dosing of algaecides, antibiotics and other additives in aquaculture. This in turn reduces the amount of drug residues and heavy metal accumulation of the aquatic end-products. Beyond aquaculture, this technology is also applicable for ensuring the health of ornamental aquariums, such as infection of pathogens as well as preventing algal bloom in natural water bodies. This technology consists of a novel composite material with algicidal effects and a real-time monitoring system. Novel Composite Material Sustained release effect which releases active ingredients into water for more than one month (customizable) Comparable algicidal rate with best-performing commercially available algaecides Silica-based porous material No harmful residues, broken down into sand at the end of its life cycle Does not contain heavy metals or antibiotics Real time monitoring system Real-time data on residual chlorine, temperature and pH Modifiable based on application scenario The technology has been employed for water quality maintenance in salt water reservoirs, large scale shrimp and fish ponds, and also for domestic applications in aquarium water quality. In general, it can be used in urban and rural water bodies, fish tanks, swimming pool or seafood restaurants. The estimated market size for solutions dealing with HABs is 68.56 US Billion. This breakthrough technology suitable for the aquaculture industry, aquarium industry and natural water protection area is poised to disrupt this industry. Current methods of algal bloom treatment: Most commercially available algicides only last 1-3 days Natural water bodies employ engineering methods that are costly and require a long time to take effect Home-based aquariums have to perform water changes, which takes time and may harm the fish The aquaculture industry uses algaecides that contain heavy metals and antibiotics, which leave toxic residues in the fish This technology: Provides long acting sustained release and precise dosing to save time, manpower and cost Contains environmentally friendly materials not harmful to marine life and marine ecosystem Can be used as a preventive measure rather than curative Incorporates digitized management to reduce manpower requirements Algal Bloom Control, Algicide, Long-term effect, Environmentally friendly Environment, Clean Air & Water, Biological & Chemical Treatment, Sensor, Network, Monitoring & Quality Control Systems

Globally, the packaging industry faces increasing pressure to reduce its environmental footprint, particularly with the impending implementation of regulations in Europe which requires all packaging to be recyclable or biodegradable by 2025. Traditional packaging materials, often derived from petroleum-based plastics, contribute significantly to environmental pollution, creating waste that takes decades to degrade. Moreover, in industries such as agriculture and food logistics, packaging is often not optimised for moisture resistance, leading to increased spoilage and product damage during transport and storage. This eco-friendly packaging technology, made from natural rubber latex, is fully biodegradable while retaining its cushioning and protective capabilities. Its moisture-resistant properties make it particularly ideal for fresh produce, offering reliable protection throughout transportation and storage. Designed for businesses in the fresh produce sector—such as farmers, packers, and exporters—this sustainable packaging solution meets strict environmental standards while minimizing fruit waste. By providing superior protection, it helps businesses reduce spoilage and product loss, ensuring that goods arrive in optimal condition. The technology owner is looking to collaborate with partners in the packaging, logistics, and agricultural industries to co-develop, testbed and implement this sustainable packaging solution across various sectors. Made from natural rubber (a renewable resource), this packaging material is biodegradable and engineered to provide effective protection and cushioning properties. Some key features of this sustainable packaging material include: Moisture-resistant - making it ideal for fresh produce and other sensitive goods Good shock absorption properties - to protect fragile items during transportation Flexible and adaptable - customisable to meet specific customer needs Eco-friendly Potential applications include (but not limited to): Fresh Produce Packaging: Ensures fruits and vegetables remain intact during transit, reducing spoilage and extending shelf life Fragile Goods: Ideal for cushioning electronics, glassware, and other delicate items E-Commerce and Consumer goods: Provides an eco-friendly cushioning solution for online retail packages Pharmaceuticals and Health Products: Protects sensitive medical products from damage during shipment while adhering to sustainability guidelines This biodegradable packaging technology offers a unique combination of sustainability, durability, and moisture resistance. It offers a packaging solution for industries looking to comply with stringent environmental regulations while maintaining product safety and integrity during transportation. Its ability to reduce both packaging and food waste and protect moisture-sensitive goods enables adopters to shift toward sustainable packaging. sustainable packaging, fresh produce, eco-friendly, impact, protection, moisture resistant, natural, rubber, latex, packaging, composite, fruits, vegetables, food packaging Materials, Plastics & Elastomers, Composites, Foods, Packaging & Storage, Sustainability, Circular Economy

Nocturia is a common urinary complaint where one experience interruption of sleep with one or more times at night to void. The current assessment of nocturia is primarily clinical and relies mainly on patients documenting their own bladder diary to complete a Frequency-Volume Chart (FVC) of volume and times of urination between a 24-to-72-hour period. This conventional way of assessment is a manual and inadequate way of diagnosing nocturia. An individual is diagnosed with nocturnal polyuria if the total urine output at night exceeds one-third of total daily output. This technology has developed a point-of-care urine osmometer for the monitoring and profiling of day- and night-time variation in urine osmolality, providing clinicians with valuable insights to facilitate more accurate, objective diagnosis and personalized treatment plans for nocturia. This device is portable and attached with a readout sensor, designed to be user friendly. The technology owner is seeking collaborations with: Medical Institutions and Healthcare Providers: To facilitate clinical validation, implementation, and integration of the portable urine osmometer into routine diagnostic practices for nocturia and other related conditions. Device Manufacturers: To miniaturize the prototype, scale up production, ensure quality control, and help bring the device to market. Research Institutes: To collaborate on further R&D , particularly in optimizing the technology and exploring additional applications, such as hydration monitoring for athletes and military personnel. Data Analytics Partners: To develop advanced software and algorithms for precise data interpretation, which can enhance the device’s diagnostic capabilities and provide more personalized treatment options. Current state-of-the-art for urine osmolality measurement uses a freezing point osmometer, which is often bulky, expensive, and requires specialized training to operate. To address these limitations, a portable urine osmometer that uses impedance measurement coupled with refractive index measurement and activated carbon absorption was developed. This innovative approach provides a quick and accurate measurement of urine osmolality. In a clinical trial involving 225 urine samples, an accuracy of 94.4 ± 5.0% was achieved, comparable to the gold standard freezing point osmometer. The device's compact design allows for easy home use, making it ideal for patients with nocturia to monitor their condition without frequent clinic visits. The current pain point in diagnosing and managing nocturia lies in the absence of an objective and quantitative method. Current clinical diagnosis relies heavily on a cumbersome 3-day bladder diary, which is insufficient but also results in inaccuracies and poor patient compliance. Consequently, urologists are left with the challenging task of providing a diagnosis for the underlying cause of nocturia which may lead to a trial-and-error approach on the medications prescribed. This results in suboptimal management of the condition, leading to unresolved patient discomfort and dissatisfaction. The proposed solution aims to revolutionize the approach to diagnosing and treating nocturia by introducing a portable point-of-care device for urine osmolality profiling. The portable urine osmometer is not only useful for diagnosing nocturia but has potential applications in assessing, monitoring hydration status and renal function in various populations, particularly in athletes, elderly, and military personnel. The market potential for portable urine osmometer, particularly in addressing nocturia, is significant. The global market for nocturia-related drugs is projected to grow at a compound annual growth rate (CAGR) of 6.1%, highlighting the increasing demand for effective nocturia management solutions. Given the high prevalence of nocturia, with approximately 1 in 10 people experiencing moderate to severe symptoms, and the current limitations of diagnostic methods, there are substantial opportunities for a portable urine osmometer. This device offers a cost-effective and accessible alternative to the traditional freezing point osmometer. This technology offers a more precise measurement in assisting physicans on the diagnosis for nocturnal polyuria and providing significant improvement to patient protocol. Besides that, the technology enhances several UVP over the conventional methodology which includes: Providing a comprehensive day and night urine osmolality profile in a home setting with an objective and quantitative readout over the current reliance on subjective bladder diaries.  Compared to existing devices in the market, this device has a much smaller footprint than a laboratory based freezing point osmometer. The device is simple to use and enables a cheaper manufacturing cost. It has a short turnaround time with a 3-minutes readout duration.  An affordable consumer device as the consumable per test is a plastic container pre-filled with activated carbon and a disposable urine container.  Urine, Osmolality, Osmometer, Nocturia, Nocturnal Polyuria, Urine Concentration Healthcare, Diagnostics, Medical Devices

Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder that affects motor neurons in the spinal cord and brain which causes progressive degeneration of muscle control. The onset of ALS usually starts between the ages of 40 to 70 and affects approximately two to seven individuals per 100,000 people globally, with an average survival time after diagnosis ranging from two to five years.  ALS is hard to diagnose at an early stage due to similar symptoms with other diseases and no one single test to specifically diagnose ALS.  Several diagnosis methods include electromyogram, nerve conduction study, MRI, blood and urine tests, lumbar puncture, muscle and nerve biopsy. The absence of definitive biomarkers complicates early diagnosis and monitoring of disease progression, while the subtle and variable symptoms often leads to misdiagnosis or delays in care. This research introduces a novel predictive model for ALS that leverages deep learning techniques alongside patient-derived induced pluripotent stem cells (iPSCs). By employing advanced machine learning algorithms, the study analyzes cellular and genetic data from iPSCs to uncover patterns associated with ALS progression. It also incorporates image analysis of motor neurons derived from iPSCs of both ALS patients and healthy individuals, utilizing a convolutional neural network (CNN) model that achieves classification accuracy. This innovative approach aims to deepen the understanding of ALS mechanisms and facilitate early diagnosis and personalized treatment strategies, potentially transforming the management of neurodegenerative diseases. The research institute is seeking for clinical studies partners and pharmaceutical companies for collaboration. Induced Pluripotent Stem Cells (iPSCs): Use of patient-derived iPSCs to study cellular responses related to ALS. Convolutional Neural Network (CNN): Implementation of a CNN model for image classification of motor neurons derived from both ALS patients and healthy controls. Identification of patterns in cellular and genetic data correlated with ALS progression is used to develop a model that can predict disease outcomes. High Classification Accuracy: Achieving a high area under the curve (AUC) of 0.97, indicating effective classification performance. Clinical Relevance: Focus on enhancing early diagnosis and personalized treatment strategies for ALS. Early Diagnosis: It helps in diagnosing diseases like ALS at earlier stages, which is crucial for timely treatment. Personalized Medicine: iPSCs reflect a patient’s unique genetic background, enabling tailored treatments and drug testing. Disease Modeling: The method allows for creating precise disease models to understand progression. Drug Screening: Researchers can test the efficacy of potential treatments on iPSC-derived cells before clinical trials. The global neurodegenerative disease therapy market is valued at around $30 billion to $40 billion and is expected to expand significantly over the coming years, with projected annual growth rate (CAGR) of approximately 6% to 8% through the next decade, driven by increasing prevalence of neurodegenerative disorders, advancements in research and technology, and growing demand for effective treatments. Major segments within the market include therapies for Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s disease, and Multiple Sclerosis (MS). By using patient-derived iPSCs, the method reflects an individual’s genetic makeup, allowing precise modeling of ALS-affected motor neurons. The integration with a convolutional neural network (CNN) provides high diagnostic accuracy (AUC of 0.97), outperforming human analysis. This approach holds promise for early diagnosis, personalized treatment, and advancing our understanding of neurodegenerative diseases through non-invasive, patient-specific models. Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis (ALS), Induced Pluripotent Stem Cells (iPSCs), Cellular Data, Genetic Analysis, Early Diagnosis, Convolutional Neural Network (CNN), Personalized Treatment Healthcare, Diagnostics, Telehealth, Medical Software & Imaging, Pharmaceuticals & Therapeutics