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Tretinoin is a vitamin A derivative under the family of Retinoids which functions by exfoliating the surface of the skin to allow regeneration of the skin epidermis and acts as an anti-aging treatment through reduction of wrinkles fine lines. Tretinoin is the most used substance for acne and photoaging treatment. While retinol is an Over the Counter (OTC) product, Tretinoin is a prescription strength drug with faster regeneration for the epidermis layer compared to retinols which must be converted twice to its active form retinoic acid. The current Tretinoin, though effective, may produce strong and irritation side effects for individuals who are more sensitive with the possibility of a Tretinoin purge escalating an increased initial outbreak before subsiding and reaching a long-term control of acne outbreaks. In the market, moisturizing cosmetics products are mixed with Tretinoin for the purpose of whitening effect which is not ideal. The technology provider has developed a derivative of Tretinoin, a synthetically modified new compound called Tretinoin Potassium Salt without the side effects of peeling skin and is tested to be more effective and safer than Tretinoin in both efficacy and toxicity. Besides its application in cosmetics, Tretinoin Potassium Salt (potassium all-trans retinoate) has also shown to inhibit apoptosis and metastasis in neuroblastoma, breast cancer and lung tumors. Non-clinical trials tests were conducted and concluded.   The technology company is seeking for partners to conduct clinical trials for FDA OTC Monograph certification and license Tretinoin Potassium Salt as an active ingredient for cosmetic and pharmaceutical purposes. Tretinoin Potassium Salt has a higher absorption rate and skin residual rate than Tretinoin in a comparative animal application test of the same dose, exhibit improved skin inflammatory protein and related gene inhibitory effect with no eye irritation, and a skin irritation index (P.I.I) of less than 3. The non-clinical trials include: In vitro: Acne bacteria application test, cancer cell (breast cancer & neuroblastoma) MTS cell survival assay, Migration, Invasion In vivo: API oral pharmacokinetics (PK) Regulation (In vivo): Skin pharmacokinetics (PK), Skin pharmacodynamics (PD), Local toxicity (TK), Formulation (substance is soluble in water). CMC: GMP standards and test methods for APIs A new substance is needed to prevent misuse of Tretinoin, which is used in combination with cosmetics. Tretinoin Potassium Salt was developed as a solution, and when registered as an OTC Monograph, it can be sold as an OTC drug for melasma treatment and whitening functional cosmetics at retail marts, pharmacies, department stores, and duty-free shops around the world. The technology company holds four synthetic and drug use patents for Tretinoin Potassium Salt. Upon registration with OTC Monograph and International Cosmetic Ingredient Dictionary (ICID), there are plans to license the patent to major production and sales countries for normal use and sales rights. Total Addressable Market (TAM) for the whitening market is $12 billion. This new ingredient has a dual function of anti-acne and melasma which could expand the ballpark Service Available Market (SAM). The core ingredient is about 10% of the sales price of cosmetics and there are plans for earning 5% of sales from granting license rights.  There are a total of six substances (Mulberry Extract, Arbutin, Ethyl Ascorbyl Ether, Oil-soluble licorice Extract, Ascorbyl Glucoside, Magnesium Ascorbyl Phosphate) registered in the OTC Monograph as raw materials for cosmetics and pharmaceuticals for whitening purposes. However, all are Tyrosinase Inhibitors related to melanin pigment. Tyrosinase inhibitors work by blocking the enzyme tyrosinase. Because melanin can absorb, scatter, and reflect light, it protects the skin and maintains body temperature by controlling the number of ultraviolet rays absorbed by the skin. Long-term blockage of melanin production through tyrosinase inhibition has a skin whitening effect, but on the other hand, light can lower immunity and cause side effects on the skin. This technology of ionised Tretinoin Potassium Salt promotes cellular turnover activity that regenerates cells from the dermal layer to the epidermal layer in just 14 days compared to the usual 28 days cycle which increases with age till a 60-day cycle. Validation studies have shown the newly discovered compound to be of high skin absorption, retention improvement, low hydrophobicity, little irritation on direct application and can be administered orally. Acne Treatment, Tretinoin, Tretinoin Potassium Salt, Whitening, Melasma, OTC, Ethical drug Personal Care, Cosmetics & Hair, Healthcare, Pharmaceuticals & Therapeutics

Augmented Reality (AR) Artificial Intelligence (AI) Glasses are transforming the landscape of industrial and field applications. Designed to streamline processes and improve efficiency, these glasses are a ground-breaking solution to the necessity of instant, accurate, and engaging data presentation.  Housed in a pioneering, lightweight design, these AR AI Glasses effectively address the challenges faced with conventional AR devices, including their bulky nature, short-lived battery life, and limited connectivity. By ensuring an incredibly low heat signature, extended battery life, and compatibility with Wi-Fi, 4G, and 5G networks, these glasses have been developed with users' comfort and usability in mind, ensuring efficient performance throughout the day.  These glasses are a valuable asset to a variety of sectors, such as manufacturing, logistics, healthcare, and construction, that value precision, efficiency, and safety. By seamlessly integrating sophisticated technologies like AR and AI into everyday operations, the glasses eliminate the need for extensive staff retraining or major procedural changes. They provide real-time information, enhance remote collaboration, and come with built-in security features like facial recognition, promising to fundamentally change how tasks are executed within these industries.  The AR AI Glasses blend advanced software and state-of-the-art hardware -  Hardware:  Featherweight Design: The glasses weigh at a mere 46g, ensuring all-day comfort.  Robust Build: Designed to endure, these glasses are IP67 rated and explosion-proof, making them ideal for a variety of demanding environments.  Minimal Heat Signature: A top heat signature of ≤40°C prevents discomfort during extended use. Extended Battery Life: The glasses offer 3.5 hours of continuous operation, which can be boosted to 10 hours with an auxiliary power bank.  Software:  Uninterrupted Connectivity: These glasses are designed to support Wi-Fi, 4G, and 5G networks, ensuring seamless connectivity and data transfer.  Secure Communications: These glasses are designed to provide secure communication channels, offering a reliable platform for data exchange.  Tailored Application Development: The technology supports the development of custom applications, allowing solutions to be tailored to unique business needs.  Remote Collaboration: Leveraging a SaaS Platform, these glasses are designed to support remote assistance, monitoring, training, and assessment.  Step-by-step SOP Support: This technology can break down complex procedures into manageable step- by-step instructions using video, image, and text.  Facial/Object Recognition: A key feature that validates objects/identity of individuals.  Optimal technology partners encompass the entire value chain, ranging from AR/VR application developers for software improvements, to hardware manufacturers responsible for producing and upgrading the glasses. Network service providers too can play a crucial role in enhancing connectivity. Industries such as manufacturing, logistics, healthcare, and security, where operational efficiency and precision are paramount, represent key sectors that would benefit from this technology. The AR AI Glasses has a broad array of potential applications across diverse sectors, from manufacturing and logistics to healthcare and construction.  Manufacturing: These glasses can streamline operations through real-time communication and guidance, allowing for remote collaboration and training. The in-built SOP functionality can simplify complex assembly procedures, minimizing errors and bolstering productivity.  Logistics: These glasses can transform inventory management, tracking, and overall operations by providing real-time information access and facilitating remote collaboration. The result is a more efficient and streamlined logistic operation.  Healthcare: The remote collaboration functionality of the glasses can be a boon for telemedicine. It allows for remote consultations, training, and guidance, ensuring that distance is no longer a barrier to quality healthcare.  Construction: These glasses can enhance on-site safety by providing step-by-step SOPs to workers. In addition, real-time patrolling and threat assessment become feasible with these glasses.  The products that can leverage this technology are not confined to the glasses themselves. They extend to software solutions tailor-made for specific industries to maximize the use of AR AI Glasses.   The augmented reality (AR) and artificial intelligence (AI) market, which includes devices such as this AR AI Glasses, is poised for a significant growth.  The industrial sector is undergoing a significant shift towards digitization and automation. This evolution calls for innovative, technology-driven solutions, such as this AR AI Glasses. By enhancing worker safety, boosting efficiency, and refining processes, these glasses offer immense value to industries ranging from manufacturing and logistics to healthcare and security.  With the advent of 5G, rapid and secure data transmission and seamless communication to and from compatible devices, such as these glasses, has become a possibility and this further increases their market adoption. These AR AI Glasses represents a significant improvement over traditional AR technology, featuring an array of cutting-edge specifications tailor-made for industrial and field environments. These glasses depart from the norm, offering a solution that is not only lightweight and comfortable but also resilient and specifically designed for enduring use in demanding work scenarios. These AR AI Glasses offer the following unique benfits - Lightweight and comfortable design for long term usage. Remote collaboration capability. Inbuilt facial recognition feature. Support for customized application development to allow modifications to suit unique operational needs. Compatibility with Wi-Fi, 4G and 5G networks to leverage evolving communication technologies. Secure and seamless data sharing and communication.   AR, VR, AR Glasses Infocomm, Video/Image Processing, Augmented Reality, Virtual Reality & Computer-Simulated Environments, Healthcare, Telehealth, Medical Software & Imaging

Effective tracking and management of Work-In-Progress (WIP) and inventory across a manufacturing facility are key to maintaining productivity and operational efficiency. Despite this, misplaced inventory and inefficient tracking remain common problems within the sector, leading to time wasted on locating items, losses due to unaccounted inventory, and ultimately, a reduction in productivity.  To tackle these challenges, an innovative solution has been developed that integrates advanced technologies, sophisticated hardware, and robust software features to optimize manufacturing operations. This solution provides real-time traceability of WIP and inventory throughout a factory, thereby reducing time wasted in locating items and preventing losses due to unaccounted inventory.  The solution seamlessly integrates with various systems including Manufacturing Execution Systems (MES), Preventive Maintenance (PM) systems, and Enterprise Resource Planning (ERP) systems. This integration capability allows it to trigger alerts, visualize processes, and reduce waste, thereby streamlining operations and minimizing inefficiencies.  The track and trace solution are an amalgamation of sophisticated state of the art hardware and software components – Hardware: Custom made racks and retrofits. LF/HF/UHF RFID for tagging and tracking. Barcode scanners for identification. Pick-to-Light systems for order picking. Weight sensors for inventory measurement. AI driven video analysis for surveillance and tracking. Software: Work in progress (WIP) tracking. Inventory management. Preventive maintenance (PM) material tracking. In line material ordering. Data analytics. The ideal collaboration partners for this solution would be manufacturing firms looking to optimize their operations, manufacturing execution system (MES) providers for system integration, hardware manufacturers for creating customized racks and hardware components, and technology companies focusing on RFID, AI, and data analytics. These partners would collectively contribute to the development, implementation, and continual enhancement of the track and trace solution. The track and trace solution has wide applicability across a multitude of manufacturing industries where tracking and managing of tools, parts, and Work-In-Progress (WIP) items is crucial. Key industries include semiconductor manufacturing, automotive production, aerospace manufacturing, and other large-scale industrial setups. In semiconductor manufacturing, it can be used to monitor the movement of sensitive materials like wafers and reticle masks. For the automotive and aerospace industries, it could be used to track the assembly of complex components, ensuring that all parts are accounted for and in the correct location. The system's flexibility allows it to be applied on both large and small scales, catering to a vast range of operational needs. Its potential applications aren't limited to the tracking of physical items; the data it gathers can also be used for predictive analytics, proactive replenishment of inventory, and enhanced forecasting, among others. Consequently, products that can be marketed based on this technology range from inventory management systems and predictive maintenance solutions to data analytics software. The complexity of manufacturing processes continues to rise, fuelling the need for innovative and advanced tracking and traceability solutions. The increasing emphasis on lean manufacturing, cost-cutting, and waste reduction are some of the driving forces behind this demand. Given these factors, the global market for such solutions is on an upward trajectory. As industries become more technologically reliant and digitized, the emphasis on precise, real-time tracking and traceability will only amplify. The market size, already sizable, is projected to witness substantial growth in the coming decade. This technology is particularly attractive to the market due to its multi-faceted benefits - it does not merely track and trace, but also integrates with existing systems, enhances forecasting, and significantly improves operational efficiency. It's robust set of features and the capability to address multiple pain points make it an appealing choice for businesses across the manufacturing sector. The track and trace solution provides a significant advancement over the current "State-of-the-Art". While traditional systems offer tracking and traceability, they often fall short when it comes to real-time data, seamless integration with existing systems, and the use of advanced technologies. This solution addresses these gaps by providing real-time tracking and traceability across the entire manufacturing process. This significantly reduces waste, enhances productivity, and improves operational efficiency.  In addition to superior tracking, this solution incorporates technologies like RFID and AI-based Video Analytics, providing unprecedented levels of precision and data insights. This also facilitates enhanced forecasting and inventory management capabilities, enabling businesses to better predict and meet their needs. The solution seamlessly integrates with existing Manufacturing Execution Systems (MES), Preventive Maintenance (PM) systems, and Enterprise Resource Planning (ERP) systems. This feature ensures that businesses can implement the solution without significant disruption and harness their current platforms to achieve better efficiency. Equipment, WIP, Material Control Infocomm, Video/Image Analysis & Computer Vision, Manufacturing, Assembly, Automation & Robotics, Robotics & Automation, Logistics, Inventory Management

Along with the global aging population, the number of people with dementia is also increasing. Moreover, digitalization of society is isolating elderly people. Enjoyable learning using digital devices can be the solution. The product is in the form of a table with a touch screen on the surface. The embedded software is connected to the contents server, which provides various programs such as visual perception and cognitive tests, videos, trainings, and analysis results. They prevent brain aging by stimulating both the left and right brains. The product is beneficial to children as well. The rich educational contents are designed to develop the problem solving ability and the metacognitive ability. The training course includes solid figures, basic Korean, mathematics, and adages etc. Analysis results are also provided to compensate for a vulnerable subject. In addition, safety education and news from local education offices are provided in conjunction with the government. It consists of a capacitive touchscreen, Android OS, and a form of a table. Up to four people can use it together. For convenience, it is able to turn the screen upside down. In terms of software, the digital contents are operated on a subscription basis and constantly updated. Since it is designed for both the children and elderly people, it’s suitable for all types of families. Nursing homes and educational institutes are also appropriate. Welfare agencies, nursing homes, educational institutes and households are potential customers. Distributors of electronics and device manufacturers, geriatricians and specialists in education are ideal partners. One of the standout features of our product is its ability to diagnose the learning outcomes and processes of individual learners. By meticulously assessing each learner's progress, we can provide tailored feedback that helps them maximize their potential and achieve their educational goals. This personalized feedback loop ensures that users are not just consuming content but actively engaging with it to enhance their cognitive abilities and creative thinking skills. In contrary to the existing cognitive learning tools (only analog), the product is a combination of digital and analog. Therefore, new contents are consistently provided. Also, it can provide education suitable for both children and the elderly. The problems are designed with a structure, it has high scalability and usability. And the contents are based on Triarchic Theory of Intelligence, Torrance Tests of Creative Thinking, Wechsler Preschool and Primary Scale of Intelligence, Creative Problem Solving, and CNS Vital Signs. Also, it diagnoses the results and processes of learning and provides feedback for each learner. It is subscription-type for B2C business and it can be used as a digital treatment through clinical trials after collecting the user’s data. What sets our product apart is its structured problem-solving approach, which not only ensures a well-defined learning path but also boasts exceptional scalability and user-friendliness. Furthermore, our educational content is underpinned by a rich theoretical foundation, drawing from renowned frameworks such as the Triarchic Theory of Intelligence, Torrance Tests of Creative Thinking, Wechsler Preschool and Primary Scale of Intelligence, Creative Problem Solving, and CNS Vital Signs.     Infocomm, Educational Technology

Integration of different machinery to the MES systems and facilitating interaction between them is a common theme in Industry 4.0 implementation. This task can become complicated due to the presence of multiple vendors and legacy systems on the production floor. This invention is a software stack which can be classified as a middleware or control software. The middleware offers an intermediary communication for the different standalone machines to communicate and perform synchronised functions. The system can further be customised to extend its functionality to suit an end user's needs. The middleware was developed to integrate robotic and automation elements allowing different machines to communicate through the middleware console. This is a set of customisable software code developed for the purpose of communicating through the interfacing ports with different machines. Customisation for the disparate systems Options to connect by augmenting existing systems through sensorisation of systems. Allows heterogeneous systems to operate with customisation.   The middleware can be used in any production floor to allow easy and non intrusive integration for synchronised operations. The solution also allows integration of legacy sytems, with no existing capability, to common Manufacturing Execution Systems (MES). This is a critical step for adoption of Industry 4.0 standards and consequently adding a capability to make data driven decisions in the production floor. The technology is customizable and can be adopted to different scenarios regarding MES integration and synchronised functioning of equipment. Industry 4.0 has made sweeping changes to how products are manufactured and production floors are managed. One of the challenges in the adoption which still exists,  is the presence of expensive but legacy systems which cannot be easily replaced. In Singapore, manufacturing sector accounts for close to one fifth of the GDP. To modernise the manufacturing sector, the problem of integration needs to be solved as it is not always feasible to replace a legacy production capable system with a new one. The middleware was developed to integrate robotic and automation elements allowing different machines to communicate through the middleware console. This is a set of customisable software code developed for the purpose of communicating through the interfacing ports with different machines. Allows digitalization on legacy systems not conforming to the standard MES requirements. System works separately on the edge and together with capability to integrate addition sensor inputs, it can provide data to a database or provide OPC UA compatibility for use by the MES. Allows non-intrusive sensorization for different brands of equipment. control software, Machines Integration, Middleware, MES, Manufacturing Execution Systems Infocomm, Networks & Communications, Manufacturing, Assembly, Automation & Robotics, Robotics & Automation

As climate change continues to cause rising temperatures and unpredictable droughts, the resulting environmental degradation and poor soil conditions have negative impacts on plant health and nutrition, ultimately affecting crop harvests and the global food chain. In Singapore, these changes threaten the very heart of the city's reputation as a garden city, including greenery, carbon sequestration, and aesthetically pleasing landscapes. To combat these issues and improve greening outcomes and land yield, enhancing soil conditions and plant resilience is crucial. One significant issue that needs addressing is soil water repellence, which prevents water from penetrating the soil, leading to rapid evaporation and reduced plant growth. This problem becomes more severe on sloping terrains like mounds and hillsides, where water is more likely to run off causing additional issues like soil compaction and disease. Soil water repellency also affects the hydrological and geomorphological properties of soil, leading to reduced infiltration capacity, accelerated soil erosion, uneven wetting patterns, development of preferential flow, and the accelerated leaching of agrichemicals. This technology refers to a specifically engineered nanogel formulation that controls water retention and release in dry soils. The nanogel formulation can uptake water-soluble nutrients and release them when needed. It has the potential to not only improve reclaimed land but also convert dry land into productive land that supports crop cultivation. The nanogel formulation can be tuned with varying retention capabilities based on underlying soil conditions and has been extensively tested in different plant species. The technology provider is currently looking for test-bedding partners from the agricultural industry and interested environmental NGOs.   Scalable fabrication method using Generally Recognised as Safe (GRAS) materials Nanogel formulation engineered for controlling water retention and release in dry soils. The nanogel formulation can uptake water-soluble nutrients and release them when needed. The formulation has the potential to convert dry land into productive land that supports crop cultivation, aside from improving reclaimed land. Different nanogel formulations with varying retention capabilities based on underlying soil conditions have been developed and extensively tested for various horticulture plants. Sustainable Landscaping Horticulture plants Reforestation Ensuring food security The global soil conditioners market grew from $5.6 billion in 2022 to $5.93 billion in 2023 at a compound annual growth rate (CAGR) of 5.9%. A tunable & eco-friendly nanogel formulation to help in the retention and release of moisture and/or nutrients in sandy soils for improving crop and flora survivability. Reduced irrigation or water consumed by agriculture  Reduced labor cost & fertiliser consumption  Increased areas of land available for farming  Hydrogel, Water retention, Soil, Agriculture Materials, Bio Materials, Life Sciences, Agriculture & Aquaculture, Sustainability, Food Security

Effective wound care requires a multi-modal approach, including wound bed optimization, management of medical conditions, and consistent follow up. Wound care products play a key role in effective wound healing. Currently, most of the commercially available dressings are intended to maintain a dry wound environment or manage infection. Biomedical innovations aimed at improving rates of healing include the use of active biologics or animal-derived collagen. However, these strategies have high infection risks, scarring potential and are too costly for long term use. This technology has incorporated biomolecules that promote skin regeneration into synthetically fabricated polymer filament to develop a bioactive wound care product used to enhance wound healing, reduce inflammation and scarring potential. Through a patented methodology of blending polymers, Polyethylene (PE) or poly (lactic co-glycolic acid) (PLGA) with biomolecule copolymer additives such as oligopeptides derived from collagen, laminin, or oligosaccharides from Hyaluronic Acid (HA), these polymers are made bioactive to be used to coat existing wound dressings such as non–woven gauze, foam dressings or fabricated into dermal matrices for burn care and deep wound management. The bioactive polymer can be produced via conventional methods such as dip coating or 3D Printing. Depending on the type of wounds (exudative, dry, partial thickness, full thickness or highly inflamed), the right type of dressing can be applied through a selection of basic carrier (gauze, foam, matrix) followed by the active layer required. The technology owner is seeking out-licensing, R&D and clinical collaborations with wound care and medical device companies.   Acellular: Wound dressings do not contain any active biologic or animal-derived ingredient. They are fully made of bioactive synthetic polymers. Biocompatible: Biomolecules attached are either peptide sequences of collagen and laminin which are essential components of extracellular matrix, or short chain Hyaluronic Acid (HA). Regenerative: Biomolecules incorporated facilitate skin regeneration. Permeable: Air and water permeable non-woven gauze, polyurethane foam and 3D-printed dermal matrices with unique pores allow for air and moisture exchange. Low allergen risk: Does not use any biologics. Wound dressings are made of bioactive polymers with low risk of allergy. Low cost: Production cost is at least 10x less than current dermal matrices made of animal collagen. Customizable: 3D-printing technique allows for personalized treatment. Long Shelf-Life: Product is fully synthetic and stable at room temperature. Hence, cold chain logistics is unnecessary, and hospitals can stock up on product. The applications include but are not limited to: Incisional/Surgical wounds  Burn wounds  Trauma wounds  Chronic wounds (e.g., diabetic ulcer wounds) Plastic reconstruction Skin graft donor sites Superficial wounds Laceration wounds The medical non-woven gauze market share is estimated to reach a value of nearly US$ 28.9 Billion by 2032 expanding from US$ 19.7 Billion in 2021. Dermal matrix market is expected to reach US$ 17.3 Billion with CAGR of approximately 15.1% by 2027 from US$ 6.5 Billion in 2020. Conventional wound care products for exudate or infection management are rarely designed with skin regenerative property. Current clinical gold standard for full thickness wound management or burn care involves the use of animal-derived collagen which has high infection risk. Cell therapies are costly and rarely used in clinical practice. This acellular synthetic wound care products with skin regeneration and inflammation reduction properties is a potential game changer in wound care market with its long shelf-life and low production cost. Bioactive polymers, Foam dressing, Wound healing, Non-woven gauge, 3D printing Healthcare, Medical Devices, Pharmaceuticals & Therapeutics, Chemicals, Polymers

Photodynamic therapy (PDT) is a highly targeted treatment modality activated through light-based photooxidation process where a photosensitizer (PS) molecule upon illumination by visible or near infrared light, produces Reactive Oxygen Species (ROS) that invokes cellular death. This technology surfaced two newly discovered synthetically modified Eosin Y analogue compounds, E3B and E5B as organic PS for targeting Gram-positive bacteria, in particular Methicillin-Resistant Staphyloccocus aureus (MRSA), without non-specific killing of normal mammalian cells. Microbial infectious diseases caused by multidrug resistant pathogens are a constant severe threat to global public health. PDT is a form of antibiotic-free phototherapy to efficaciously treat microbial infections with advantages in spatiotemporal controllability, non-invasiveness, minimal off-targets and side effects, and broad antimicrobial spectrum. However, the promise of PDT in antibacterial intervention has not been fully fulfilled particularly using conventional organic PS due to restricted structural availability. Herein, we disclosed organic PS compounds, E3B and E5B, with high intracellular ROS-generation capabilities under white light irradiation at very low light dose without suffering photobleaching of traditional PSs to combat antimicrobial resistance as a promising antibacterial PDT for translation to clinical trials. The technology owner is seeking collaboration with biotech, clinical stage biotech and pharmaceutical companies to develop and commercialize new antimicrobial PDT agents superior to currently marketed organic PSs. The technology has been validated till in vivo specificity and stability studies. There are opportunities in R&D collaboration to demonstrate the interactions and characterization of the novel E3B and E5B PS with metabolites in controlled functional assays of microbial communities. E3B and E5B analogues are organic hybrid PS which can exhibit both Type I and II ROS reactions in PDT. Selective targeting of Gram-positive pathogens, in particular MRSA, to combat multidrug resistance. More targeted and efficient killing within shorter time than conventional PS (reaction time required is 2 to 5 min). No photobleaching effects exhibited and requires only a 50S white lamp which is tested in vivo. Upon a low light-dose irradiation, E3B and E5B can overwhelm the anti-ROS defence system of bacteria without drug deactivation and photobleaching. Efficient methods for synthesis of Eosin Y analogues with moderate to high yields for affordable and scalable production. No column purification required with consistent batch testing produced. This technology can be applied for antibacterial PDT to combat antimicrobial resistance under World Health Organisation (WHO) priority pathogens (e.g., MRSA the most resistant species and causative agents of skin and lung infections). The eosin derivatives, E3B and E5B have promising potentials due to their remarkable photo-antibacterial efficacies, affordability, and scalable production. Eosin Y as a universal staining agent can also be used as an imaging diagnosis for microbial infections concurrent with PDT. A superior and potent photo-activated antibacterial effects at low light dose compared to traditional PS. Able to control the illumination time, dosage, and light power. Superior therapeutic window without harming normal mammalian cells. No adjuvants required. Highly stable and accessible production method for scale-up process. Anti-bacterial photodynamic therapy, Organic photosensitizers, Eosin Y, Anti-microbial resistance Healthcare, Diagnostics, Medical Devices, Pharmaceuticals & Therapeutics, Chemicals, Organic

In manufacturing there are many instances where there is a need for low production runs of parts. These could be for parts of an equipment, tools, small volume runs for trials or customised parts. However, traditional manufacturing techniques are usually not cost-effective for such low volume runs, while current additive manufacturing suffers from low strength, long print times and poor surface finish needing post-processing. Additionally, for techniques using powder and filaments, considerations have to be given to the storage due to oxidation, degradation, flammability and toxicity of these precursor materials. The tech owner has developed a hybrid manufacturing technique that involves both additive and subtractive manufacturing methods. Instead of powder or filaments, sheets and foils are used as precursor materials, thereby alleviating cost, safety and performance concerns that were outlined. A laser is used to cut and fuse the different layers of the build.   Numerous tests conducted by the team have consistently yielded parts that are dense and displayed high strength. The system is able to work with different materials, including highly reflective ones such as, aluminium, copper. Parts using carbon fibres, composition materials, ceramics, etc have also been successfully printed. Based on initial estimates, this technique offers up to 80% cost advantage over powder bed systems. The tech owner is seeking partners to collaborate in test bedding the system for manufacturing of complex, customized and/or high strength / high thermal conductivity parts for applications in the healthcare, semiconductor, aerospace, automotive, telecoms or marine & offshore sectors. The system included an energy deposition module that is based on commercially available laser source. The slicer software and printer controller software were based on in-house developed proprietary software. These will ensure that the quality of print is able to meet the density and strength requirements demanded by the user.    Precursor material handling module is also inhouse developed to ensure consistency of print.   The current prototype has the following performance specifications: Largest print – 20cm x 20cm Smallest feature that can be printed - 100um Highly dense structure < 1% porosity Heat exchangers – micro cooling channels   Semiconductor equipment Dental/ Bone implants; Prosthetics; Surgical Tools; Aerospace parts Automobile parts Mobile Device parts (e.g. Smartphone, laptop, smartwatch shells and casings) Unlike powder bed system, there is no need for environment controlled chambers Safer and cheaper precursors (sheets and foils vs powder and filaments) Printed parts are higher strength (Example – Stainless Steel SS304L, up to 1 GPa yield strength) Printed parts are fully dense (<= 1% porosity) Lead time is significantly reduced for fully solid designs Can fabricate enclosed channels Surface roughness is 3 times smoother than powder bed techniques Minimal post-processing (e.g. sand-blasting) is necessary Compatible with different material classes (composites, metals, polymers, ceramics)   3D printing, Additive manufacturing, Subtractive manufacturing, Laser, Laser system, Powder bed, Low volume manufacturing Manufacturing, Additive Manufacturing, Subtractive Machining